PBPK models

Physiologically based pharmacokinetic (PBPK) modelling is a mathematical technique for predicting chemical substances’ absorption, distribution, metabolism, and excretion (ADME) in the human body and other animal species.

Schematic of a whole-body PBPK model

PBPK models are made of different compartments corresponding to different tissues or organs connected through the circulatory system. These models integrate physiological information with drug-specific parameters to mathematically simulate the dynamic behaviour of existing and unsynthesized compounds, offering a mechanistic understanding on how substances distribute and interact with our body.

Main advantages:

Pharmaceutical industries and regulatory bodies widely use PBPK models for more informed decision-making in the fields of pharmacology, toxicology, personalized medicine, and health risk assessment for drugs, cosmetics, or other chemicals.

Explore our PBPK models